Hit to Lead Discovery

Plex employs a wide array of biochemical assays (binding, enzyme, immunoassays) and cell-based assays (viability, apoptosis, biomarker, mitochondria uptake/function, reporter) for structure-activity-relationship studies to identify potent and selective leads. In addition to Plex’s own evolving panel of cell lines, the Plex also has access to well-characterized patient-derived cancer cell lines though collaborations with the Mayo Clinic and University of California, San Diego.